MovDisordV3, Main, Exploration, bibRecord, 004808

Erythropoietin deficiency and anaemia in multiple system atrophy

Identifieur interne : 004808 ( Main/Exploration ); précédent : 004807; suivant : 004809

Erythropoietin deficiency and anaemia in multiple system atrophy

Auteurs : Andrea S. Winkler [Royaume-Uni] ; Joanne Marsden [Royaume-Uni] ; Matthew Parton [Royaume-Uni] ; Peter J. Watkins [Royaume-Uni] ; K. Ray Chaudhuri [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2001-03.

RBID : ISTEX:9BC9B7A8B96069232628FB00EDA4D2A1A5D85ADE

Descripteurs français

Pascal (Inist)
- Adulte, Anémie, Atrophie multisystématisée, Complication, Erythropoïétine, Etude comparative, Exploration, Hypotension artérielle orthostatique, Parkinson maladie, Sérum.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Anemia, Anemia (diagnosis), Anemia (metabolism), Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (physiopathology), Cardiovascular System (physiopathology), Comparative study, Complication, Creatinine (blood), Enzyme-Linked Immunosorbent Assay, Erythropoietin, Erythropoietin (blood), Erythropoietin (deficiency), Exploration, Female, Heart Rate (physiology), Hemoglobins (analysis), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (epidemiology), Male, Middle Aged, Multiple System Atrophy (blood), Multiple System Atrophy (physiopathology), Multiple system atrophy, Parkinson disease, Postural hypotension, Serum, Severity of Illness Index, anaemia, erythropoietin, multiple system atrophy, postural hypotension.
MESH :
- chemical , analysis : Hemoglobins.
- chemical , blood : Creatinine, Erythropoietin.
- chemical , deficiency : Erythropoietin.
- blood : Multiple System Atrophy.
- diagnosis : Anemia, Autonomic Nervous System Diseases, Hypotension, Orthostatic.
- epidemiology : Hypotension, Orthostatic.
- metabolism : Anemia.
- physiology : Heart Rate.
- physiopathology : Autonomic Nervous System Diseases, Cardiovascular System, Multiple System Atrophy.
- Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO‐deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron‐deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 ± 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron‐deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications. © 2001 Movement Disorder Society.

Url:

https://api.istex.fr/document/9BC9B7A8B96069232628FB00EDA4D2A1A5D85ADE/fulltext/pdf

DOI: 10.1002/mds.1063

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO‐deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron‐deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 ± 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron‐deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications. © 2001 Movement Disorder Society.</div>
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Movement Disorders (revue)

Erythropoietin deficiency and anaemia in multiple system atrophy

Erythropoietin deficiency and anaemia in multiple system atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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